We focus on developing albumin-based nanoparticle drug delivery systems, particularly for targeted delivery of anticancer drugs and other potent therapeutics. Our services include full-process support from albumin nanoparticle formulation development, process optimization, to characterization analysis, ensuring success in both preclinical and clinical stages.
Contact us to learn more about our albumin nanoparticles.
Encapsulation and delivery of small molecule drugs, peptides/proteins, and nucleic acids (DNA/mRNA/SiRNA).
Design of encapsulation and drug-loading strategies for complex compounds.
Provision of albumin nanoparticle systems to enhance solubility.
Improvement of receptor-mediated active targeting through albumin modification
Modulation of nanoparticle responsiveness to the tumor microenvironment
Prolongation of drug half-life in vivo by PEGylating albumin nanoparticles
Alteration of nanoparticle surface physical properties to enhance targeting effects.
Covalent attachment of target antibodies to nanoparticle surfaces using conventional EDC chemistry or click chemistry.
Encapsulation of fluorescent dyes within the nanoparticle matrix or conjugation to nanoparticles.
Development of controlled-release and sustained-release drug delivery systems.
Pre-formulation studies, formulation feasibility analysis, and prototype development.
Process development, optimization, scale-up, and process validation (design of experiments).
Particle size and size distribution (DLS, NanoSight).
Surface characteristics (Zeta potential, SEM).
Drug encapsulation efficiency and drug-loading capacity (HPLC, UV-Vis).
Microstructure analysis (TEM, SEM, AFM).
Drug release profiles and in vitro release behavior studies.
Thermodynamic properties (TGA, DSC).
Cytotoxicity testing (MTT, CCK-8).
Functionalization and modification (PEGylation, antibody conjugation)
Circular dichroism spectroscopy
Fluorescent labeling and imaging.
