We are highly effective in synthesizing macrocyclic compounds, including macrolides, lactams, sulfonamides/sulfonimides, cyclic ethers, and cyclic peptides. We have successfully synthesized over 1,500 macrocyclic compounds, with the largest amount exceeding 30 grams and synthesis steps reaching up to 31.
A synthesis platform supported by more than 30 experienced chemists.
Over 1,500 macrocyclic compounds synthesized.
Supported over 10 candidate compounds.
Scaled up to 30+ grams with 20 to 31 steps.
15 years of experience in macrocyclic chemistry.
8+ representative cyclization methods.
Mitsunobu cyclization
RCM (Ring-Closing Metathesis) cyclization
Sulfonamide cyclization
Lactam cyclization
Substitution cyclization
Click chemistry cyclization
Reductive amination cyclization
C-H activation cyclization