Chelator Screening and Synthesis

1. Chelate Screening Services  

We offer more than 10 kinds of chelators, providing customized chelator synthesis, analysis, and screening services for your specific complex fewer effects on biological activity. (The chelator agents shown below are representative of our chelating agent library: DOTA/DTPA/TETA/NOTA/HBED/NETA.)

2. Chelator Synthesis Services  

We provide quantities ranging from milligrams to hundreds of grams. In addition to developing and optimizing synthetic routes, we can also synthesize chelating agents using our proprietary processes.

3. Comprehensive Route Optimization Services  

We can optimize and modify chelating agents with the most efficient synthesis path and guarantee high-quality and extreme purity chelators for lateral conjugations.

Linker Design and Synthesis  

We have successfully designed several linkers, including cationic, anionic, neutral, and metabolically cleavable linkers. Based on specific needs, the most suitable linker can be chosen. The linkers shown in the chart are part of our linker library. With years of experience in linker design services, our expert team can help you find the most suitable linker for your RDC.

Impact of Linkers on RDC  

Different kinds of linkers have different influence on the bioactive properties of RDC, depending on the specific radioactive particle, chelator, and targeting molecule you design. The linkers of RDC have the following influences:

Increasing lipophilicity

Slowing of cellular uptake

Altering pharmacokinetics

Minimizing accumulation

Improving hydrophilicity

Changing biodistribution

Increasing the tumor/liver ratios

Improving excretion kinetics

Linker Design Services  

The linker is one of the most critical parts of an RDC. With extensive knowledge in RDC development and years of experience in linker synthesis and manufacturing, our company, composed of experienced and senior scientists, is dedicated to designing the most suitable linker for your project, saving you time. The linkers we design offer the following three advantages:

Stabilize radioactive particles

Reduce the interactions between radionuclide and the targeting molecule

Modify the excretion kinetics of RDC

Linker Synthesis Services  

Additionally, with our advanced chemical platform and top-notch equipment, we guarantee a high-quality and extreme pure linker with the best synthesis pathway will be chosen.