Revolutionizing Drug Delivery with Microsphere Technology
Microsphere-based drug delivery systems have emerged as a transformative technology in modern pharmaceuticals, offering controlled release (CR), targeted drug delivery, and high drug loading efficiency. As a global leader in microsphere drug delivery, Litchlab is dedicated to developing high-performance microsphere systems for small molecules, biologics (proteins, antibodies, peptides), gene therapies (mRNA, siRNA), and vaccines. Our expertise spans the entire development cycle, from formulation to clinical translation.
Key Advantages of Litchlab’s Microsphere Technology
Litchlab’s advanced microsphere technology integrates materials science, nanotechnology, and pharmaceutical engineering to achieve high encapsulation efficiency, precise release kinetics, targeted delivery, excellent biocompatibility, and scalable manufacturing.
1. High Drug Encapsulation & Stability
Our proprietary microsphere fabrication techniques—double emulsion-solvent evaporation, spray drying, and microfluidic synthesis—enable optimal drug loading and enhanced stability:
Up to 95% drug encapsulation efficiency, ideal for small molecules, biologics, mRNA, siRNA, and vaccine antigens
Optimized interfacial chemistry to prevent protein denaturation and RNA degradation
Enhanced solubility and bioavailability of poorly soluble drugs
Application Examples: Sustained-release antipsychotics (Risperidone, Aripiprazole), long-acting insulin formulations, RNA vaccine delivery
2. Controlled Release Kinetics
Litchlab’s microspheres are engineered to precisely regulate drug release profiles, allowing for long-term therapeutic efficacy and reduced dosing frequency:
Sustained release (1–6 months) to improve patient compliance
Pulsatile release for mimicking physiological rhythms, ideal for hormone therapies
Stimuli-responsive release (pH, enzyme) to enable site-specific drug activation
Application Examples: Long-acting diabetes treatments (insulin microspheres), extended-release local anesthetics (bupivacaine), sustained-release vaccines
3. Targeted Drug Delivery
By leveraging functionalized surface engineering, Litchlab enhances site-specific drug delivery and therapeutic precision:
Antibody-conjugated microspheres for cancer immunotherapy (PD-1/PD-L1 inhibitors)
Ligand-modified microspheres for tissue-specific RNA drug delivery (mRNA, siRNA)
Magnetic microspheres for guided localization using an external magnetic field
Application Examples: Targeted chemotherapy (Paclitaxel, Doxorubicin), CNS-targeted siRNA therapeutics, CRISPR/Cas9 gene-editing delivery
4. Scalable GMP-Compliant Manufacturing
Litchlab offers seamless scale-up from R&D to commercial production, ensuring high reproducibility and regulatory compliance (FDA, EMA):
Microfluidic-based synthesis for precise particle size control and batch-to-batch consistency
Spray drying & solvent evaporation techniques for optimized encapsulation efficiency
Solvent-free processing to minimize residual solvents and enhance biocompatibility
GMP-grade production for clinical trials and commercial-scale manufacturing
Application Examples: Protein therapeutics (monoclonal antibodies, enzymes), RNA therapeutics (mRNA, siRNA), controlled-release vaccines
Clinical Applications of Litchlab’s Microsphere Technology
Therapeutic Area | Technical Benefits | Representative Drugs |
Oncology | Targeted chemotherapy, immunotherapy, reduced toxicity | Paclitaxel, Doxorubicin, PD-1/PD-L1 inhibitors |
Gene & RNA Delivery | Protection & enhanced uptake of RNA therapeutics | siRNA/mRNA, CRISPR/Cas9 gene editing |
Chronic Disease | Long-acting formulations for improved patient adherence | Insulin microspheres, steroid microspheres |
Vaccine Delivery | Controlled antigen release for enhanced immune response | mRNA vaccines, inactivated vaccines |
Pain Management | Extended-release anesthetics & opioid alternatives | Bupivacaine microspheres, opioid microspheres |
Litchlab: Pioneering the Future of Microsphere Drug Delivery
As a leader in drug delivery innovation, Litchlab leverages cutting-edge microsphere technology to overcome formulation challenges, enhance therapeutic efficacy, and enable precision medicine.
Pioneering controlled-release and targeted drug delivery solutions
Optimizing formulations to maximize patient benefits
GMP-compliant manufacturing for seamless clinical translation
For more information, please feel free to contact us at:
E-Mail:RD2@Litchlab.com